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Vesicular Stomatitis (VS) is a contagious disease that afflicts horses, livestock, wildlife and even humans. The disease is caused by a virus, which although rarely life threatening, can have significant financial impact on the horse industry. Vesicular Stomatitis is a reportable disease; in a suspect case, state and federal animal health authorities will be contacted by your veterinarian. When a case of vesicular stomatitis is confirmed, your state veterinarian’s office will quarantine the affected farm or ranch. In an effort to minimize risk of spread of the disease, horses and other susceptible species will be confined to that location for at least 14 days from the onset of the last case on that property. Equestrian event organizers may also choose to cancel horse shows, rodeos, and other equestrian activities in the surrounding area. Interstate and international movement of horses may also be restricted. 

Clinical Signs & Diagnosis 

When vesicular stomatitis occurs in horses, blister-like lesions usually develop on the tongue, mouth lining, nose or lips. In some cases, lesions can develop on the coronary bands, or on the udder or sheath. When VS is suspected, an exact diagnosis should be obtained by testing the blood for virus-specific antibodies or by testing swabs from the lesions to identify the presence of the virus. Testing is necessary to rule out the possibility that the lesions are caused by photosensitivity (sunburn), irritating feeds or weeds, or toxicity from non-steroidal anti-inflammatory medications like phenylbutazone. 

VS should not be confused with foot and mouth disease(FMD), which does not affect horses, and was eradicated from the U.S.A. in 1929. The incubation period for vesicular stomatitis – meaning the time from exposure until the first signs appear – ranges from 2 to 8 days. A fever may develop initially as blisters form on the tongue, gums, or coronary bands. One of the most obvious clinical signs is drooling or frothing at the mouth and potentially a reluctance to eat. This occurs following rupture of the blisters that create painful ulcers in the mouth. The surface of the tongue may slough. Excessive salivation is often mistaken as a result of a dental problem just as a horse that is not eating well may be suspected as having colic. Weight loss may be a secondary effect, as a horse with mouth ulcers finds it too painful to eat. If lesions form around the coronary band, inflammation within the foot may result in lameness or laminitis. In severe (but rare) cases, the lesions on the coronary band may cause the hoof to slough. 

The disease generally runs its course within two weeks, although it may take as long as two months for the sores to entirely heal. Live virus can often be isolated from the lesions for up to a week after the lesions appear.  During this time, the horse remains infective and the potential remains for the disease to spread to other animals.


While a horse is suffering from vesicular stomatitis, feeding soft feeds may reduce mouth discomfort.  Anti-inflammatory medications may be used as supportive care help to minimize swelling and pain so a horse will continue to eat and drink. If the horse becomes dehydrated from not drinking enough water, your veterinarian may need to provide additional supportive care using intravenous fluids.  Secondary bacterial infection of ulcerated areas is another concern. If fever, swelling, inflammation or pus develops around the sores, treatment with antibiotics may be required. Flushing the mouth regularly with a dilute antiseptic solutions, such as chlorhexidine in water, may reduce secondary bacterial contamination of the sores and speed healing. However, there is little more an owner or veterinarian can do but wait for healing to occur and take appropriate precautions to minimize the risk of spread of the disease to other horses and livestock. 

Disease Transmission 

There are still some questions regarding how vesicular stomatitis is transmitted and why it only occurs sporadically in the U.S. The disease is distributed only in North, Central, and South America, with a greater incidence in warmer regions. Due to the seasonal occurrence of VS during summer through early fall, it is believed that insects such as biting flies and midges contribute to maintaining the lifecycle of the virus.  Black flies, sand flies, and midges are known to transmit the virus, but there may be other insect vectors that have not yet been identified. VS also can be passed from horse to horse by contact with saliva or fluid from ruptured blisters. Physical contact between animals, or contact with buckets, equipment, housing, trailers, feed, bedding, shared water troughs or other items used by an infected horse can provide a ready means of spread. 


By observing the following guidelines you can help prevent the occurrence of VS: 

· Healthy horses are more disease resistant so provide good nutrition, regular exercise, deworming and routine vaccinations. 

· Isolate new horses for at least 21 days before introducing them into the herd or stable. 

· Observe your horse closely. Immediately isolate any horse that shows signs of infection and contact your veterinarian. 

· Implement an effective insect control program. Keep stabling areas clean and dry. Remove manure and eliminate potential breeding grounds (standing water, muddy areas) for insect vectors. 

· Use individual rather than communal feeders, waterers, and equipment. 

· Clean and disinfect feed bunks, waterers, horse trailers and other equipment regularly. 

· Be sure that your farrier and other equine professionals who come into direct contact with your animals exercise due care so as not to spread the disease from one horse or facility to the next. 

· On farms where VS has been confirmed, isolate any animals with lesions away from others and handle healthy animals first, ill animals last. Handlers should then shower, change clothing and disinfect equipment to prevent exposing others. 

· Anyone handling infected horses should implement proper biosafety methods, including wearing latex gloves and washing hands after handling animals with lesions. 

· If you are sponsoring an event during an outbreak, require a more recent health certificate on every horse entering the venue and consider having a veterinarian visually inspect all horses at check-in.  Work with your event veterinarian to establish isolation and response procedures that can be implemented quickly if a suspect case is identified at the venue.   

Vesicular Stomatitis In Humans 

Humans can contract vesicular stomatitis from infected horses. Therefore, it is important to follow proper biosafety measures when handling infected horses to protect yourself from contracting the virus. Precautions should include wearing latex gloves and avoiding direct contact with the horse’s saliva or blister fluids. Special care should be taken to keep mouth, eyes and any open wounds from being exposed to infection. Horses may sneeze or snort infective secretions, so you should stand to the side to avoid being sprayed in the face. 

Vesicular stomatitis in humans tends to cause severe flu-like symptoms such as headache, fever, muscle aches, and extreme fatigue. People rarely develop blisters in their mouths. However, if you experience influenza-like symptoms after working with a VS-infected horse, contact your physician immediately. 

Vaccines And Disinfectants 

Vaccines have been developed experimentally to help combat vesicular stomatitis, but none are currently approved for use in horses. There is considerable debate over the efficacy of vaccination in preventing or reducing the severity of an outbreak. The period of protection is thought to be fairly limited and once vaccinated, animals will test positive for long periods of time thereby incurring travel restrictions.

Sunlight and heat are known to quickly destroy the virus that causes vesicular stomatitis. Commercial disinfectants such as chlorine bleach (0.645%), Wescodyne (4 %), Roccal (1:200), Septisol (1:50), and cresylic acids (1 %) are also effective. 

Working With Your Veterinarian 

By working closely with your equine veterinarian, you can develop strategies to reduce the likelihood of a vesicular stomatitis outbreak, or to minimize the effects should one occur. Veterinarians and owners who suspect that an animal has vesicular stomatitis should immediately contact state or federal animal health authorities. For more information, contact: 

U.S. Dept. of Agriculture

Animal and Plant Health Inspection Service

Veterinary Services, Equine Epidemiologist

2150 Centre Ave., Building B, Mailstop 3E113

Fort Collins, CO 80526

(970) 494-7391


Reviewed and updated by Dr. Angela Pelzel-McCluskey in 2016.