Impact of Concurrent Treatment with Omeprazole on Phenylbutazone-Induced Gastric Ulceration in Horses

Megan Ricord, BS; Frank M. Andrews, DVM, MS, DACVIM (LA); Francisco J. Morales Yn˜ iguez, DVM; Michael L. Keowen, BS; Frank Garza, Jr, MS; Linda Paul, DVM; Ann Chapman, DVM, MS, DACVIM (LA); and Heidi Banse, DVM, PhD, DACVIM (LA)

Omeprazole ameliorates phenylbutazone-induced gastric glandular ulceration, but may increase the rate of intestinal complications. Risk of complications should be considered when co-administering omeprazole and phenylbutazone in horses.